Cell death in the gastrulating chick embryo: potential roles for tumor necrosis factor-alpha (TNF-α)
نویسندگان
چکیده
منابع مشابه
TUMOR NECROSIS FACTOR ALPHA (TNF-a)
Tumor necrosis factor alpha (TNF, TNFSF2) is an important multifunctional cytokine that regulates inflammation, host defense, immune responses, and apoptosis. TNF exists as a membrane-bound 26kDa, type II integral membrane protein, and a 17kDa soluble homotrimeric TNF that is generated via proteolytic cleavage by TNF-a converting enzyme (TACE, ADAM17). Both the membrane-bound and soluble forms ...
متن کاملTumor necrosis factor (TNF) biology and cell death.
Tumor necrosis factor (TNF) was the first cytokine to be used in humans for cancer therapy. However, its role in the treatment of cancer patients is debated. Most uncertainties in this field stem from the knowledge that the pathways directly activated or indirectly affected upon TNF engagement with its receptors can ultimately lead to very different outcomes in terms of cell survival. In this a...
متن کاملEvaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...
متن کاملDevelopment of ELISA Systems for Measurement of Human Tumor Necrosis Factor-Alpha (TNF-α)
The aim of this study was to develop a human tumor necrosis factor alpha (hTNF-α) ELISA system because specific and sensitive measurement of low levels of circulating TNF-α is very important for enlightening the immunopathologial mechanisms associated with TNF-α. Monoclonal antibodies 6A4c and 8A6 were produced against hTNF-α and were used as the capture antibody and the tracer antibody respect...
متن کاملTumor Necrosis Factor Alpha (TNF-α) Disrupts Kir4.1 Channel Expression Resulting in Müller Cell Dysfunction in the Retina.
Purpose Diabetic patients often are affected by vision problems. We previously identified diabetic retinopathy (DR) as a disease of clock gene dysregulation. TNF-α, a proinflammatory cytokine, is known to be elevated in DR. Müller cells maintain retinal water homeostasis and K+ concentration via Kir4.1 channels. Notably, Kir4.1 expression is reduced in diabetes; however, the interplay of TNF-α,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 1997
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400235